USP Chapter 621 for Chromatography: A Future Version of Empower to Meet the USP Requirements - Tip303
OBJECTIVE or GOAL
Understand how a future version of Empower will incorporate revised USP calculations and terminology.
Note: As of November 2022, the current version of Empower is 3.7.0.
ENVIRONMENT
- Empower
- Tip of the Week #303
PROCEDURE
STEP 1
The current version of Empower (3.7.0) added system suitability calculations as set forth in the Chinese Pharmacopoeia. The next version of Empower will incorporate the revised calculations and terminology of USP Chapter 621. The new version will maintain all previous calculations as legacy data (Figure 1).
STEP 2
Figure 2 provides a summary of the proposed new fields and existing fields, as well as a comparison with the European, Japanese, and Chinese Pharmacopoeias.
STEP 3
The default for the Half Height Multiplier for signal-to-noise calculations will now be 20 for USP and EP (Figure 3).
STEP 4
The System Suitability Quick Reference Guide was updated earlier this year. It will be updated again in the new version of Empower. Go to the Waters Knowledge Base for an article on this topic (Figure 4).
Note: Access to this guide requires a Software Support Plan.
ADDITIONAL INFORMATION
This can be done with either the Pro or QuickStart interface.