Skip to main content
Waters

Calculation errors with US Pharmacopoeia suitability in Empower (PCS 54414) - WKB9534

Article number: 9534

SYMPTOMS

  • When Empower cannot calculate a Width@Tangent (USP Resolution) value, it incorrectly uses the value from the previous peak (PCS 54414)
  • Most prevent with fused peaks

ENVIRONMENT

  • Empower 2 FR5 through Empower 3 SR2 HF2
  • US Pharmacopoeia selected in the "System and Suitability" section of the "Suitability" option in the processing method
  • Traditional integration algorithm only
  • Apex track integration only in rare cases where peaks are manually identified (if there is no manual integration, then this defect will not be experienced in Apex track integration)
  • Fused peaks

CAUSE

When Empower cannot calculate the Width@Tangent value for a fused peak, it incorrectly uses the value of the previous peak.

FIX or WORKAROUND

  1. Select "All" in the "System and Suitability" section of the "Suitability" option in the processing method.
  2. This fault is corrected in Empower 3 FR3 and all subsequent releases.KCS.png

ADDITIONAL INFORMATION

See the attached files related to PCS# 54414 and USP Resolution Calculations.  

Resolution_Values_in_Empower_3_-_TECN134899112.pdf

Empower__3_FR3_Release_Notes.pdf

Impact assessment of PCS 54414 - TECN134972097.pdf 

Not able to find a solution? Click here to request help.