- Solid-phase extraction
- Sample preparation
The loading capacity for Oasis HLB devices can vary greatly depending on many variables—the nature of the target compound (size, polarity, etc.), the loading solvent (organic level), complexity of the sample matrix (other retained compounds), and loading flow rate, to name only a few. Under ideal conditions, the Oasis HLB can retain up to approximately 10% of its mass during a typical solid-phase extraction. For example, a 1-cc/30-mg Oasis HLB cartridge may be able to retain up to 3 mg of a relatively hydrophobic compound being loaded slowly (around 1 mL/min) from a neat water solution. For true loading capacity values for any specific application under specific use conditions, a loading study is required.