Does Waters have any SPE methods for insulin and insulin analogs from plasma? - WKB248063

ENVIRONMENT

• Solid-phase extraction (SPE) methods
• Insulin and insulin analogs
• Mixed-mode strong cation exchange (MCX)
• Bridged ethylene hybrid (BEH)
• Oasis MCX 96-well µElution Plate
• XBridge BEH C18 Intelligent Speed
• CORTECS C18+

ANSWER

Yes, see Simultaneous Analysis of Intact Human Insulin and Five Analogs in Human Plasma Using μElution SPE and a CORTECS UPLC Column.

ADDITIONAL INFORMATION

This method uses:

• 186001830BA - Oasis MCX 96-well µElution Plate, 2 mg Sorbent per Well, 30 µm, 1/pk 
• 186003019 - XBridge BEH C18 Intelligent Speed (IS) Column, 130Å, 3.5 µm, 2.1 mm X 20 mm, 1/pk  (trap column)
• 186007114 - CORTECS C18+ Column, 90Å, 1.6 µm, 2.1 mm X 50 mm, 1/pk* (analytical column)

*Column conditioning is required. See the "Column Conditioning" section in the application note referenced above.