Do polypropylene vials show less adsorption of biomolecules versus traditional glass vials? - WKB24623

ENVIRONMENT

• Vial characteristics

ANSWER

Yes and no. Some biomolecules may adsorb less to polypropylene versus glass, and some may adsorb more.

ADDITIONAL INFORMATION

Because biomolecules adsorb to surfaces by non-specific binding, they can adsorb to polypropylene more than glass in some cases. In other cases they may adsorb less to polypropylene versus glass. It is recommended that an adsorption study be performed with the vials that are intended to be used for the specific biomolecules that are being tested. A study can help determine adsorption characteristics of a specific biomolecule to polypropylene versus glass.

In some cases, glass that has been deactivated (silanized) can lower adsorption for biomolecules that might otherwise adsorb to the very polar surface of untreated type 1,33-expansion borosilicate glass.

Learn more here:

Waters Vials and Plates Brochure

Waters LC/GC Certified Sample Vials Technical White Paper

Waters LCMS Certified Vials Technical White Paper

Waters TruView LCMS Certified Sample Vials Technical White Paper