Has Waters performed any studies to determine how long-term storage of reversed-phase columns in methanol affect lifetime? - WKB95168
Article number: 95168
ENVIRONMENT
- Column Storage
- Reversed-Phase
- Methanol
- Proton Donor Solvent
ANSWER
No.
ADDITIONAL INFORMATION
Methanol is known as a proton donor solvent.
Storage in the presence of methanol over long periods causes endcap groups and ligands to chemically hydrolyze (detach) from the particle surface.
100% acetonitrile is the preferred long-term storage solvent for reversed-phase columns.