What is the optimal flow rate range for ACQUITY UPLC reverse-phase columns to maximize the Van Deemter curves for the particle size? - WKB224746
Article number: 224746
ENVIRONMENT
- Flow rate optimization
- ACQUITY UPLC columns
ANSWER
Sub-2µm particles become more efficient in the flow rate range of 0.4 to 1.0 mL/min. Different compounds have different optimal flow rates, but every separation is a balance of physical limitations (system pressure, system plumbing, loading capacity).
ADDITIONAL INFORMATION
For additional information, see What is the relationship between particle size and optimal flow rate?
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