What is a good column choice for the USP monograph for Trolamine salicylate? - WKB102088

ENVIRONMENT

• Spherisorb
• C8
• L7
• Column
• Trolamine salicylate
• Monograph
• United States Pharmacopeia (USP)

ANSWER

PSS845280 - Spherisorb C8 Column, 80Å, 5 µm, 4 mm x 125 mm, 1/pk

ADDITIONAL INFORMATION

The specific column the USP used to validate assay and impurity testing portion of this monograph was not a Waters column. To find this information on the USP-NF online website, select "Resources" and "Chromatographic Column", and then search for the monograph for Carbidopa and Levodopa tablets.

The Spherisorb C8 column listed might have selectivity similar to the original column used. 

Use of a different column can lead to potential issues with selectivity, retention time or both.

Also see:

Waters Spherisorb Columns Brochure

Waters Spherisorb Columns Care & Use Manual

Future-Proof Solutions for Regulated Laboratories In the Face of Changing USP <621> Guidelines

Chapter and Verse: USP 621 and You (blog)